In this grant researchers have tried to harness the patients immune system to help in the recognition and destruction of dipg tumours.
Using drugs discovered in A/Prof Matt Duns laboratory, researchers have been able to categorise due to the funding of this grant how the immune system may play a role in the destruction of these tumours for patients that receive a good response to the therapies.
This is groundbreaking work that identifies that a patients immune system can be awoken, can recognise the tumour and be a part of its destruction.
$477,573
Throughout the last three years the Dun Lab has been sequencing DIPG tumours and what they have discovered is that there is a unique protein localised on the surface of the tumour cells that might be targeted with new therapeutics the lab is currently developing and thanks to this funding researchers are now actively generating new therapies that target this protein for the destruction of DIPG tumours.
The legacy of two little girls - Alegra & Josie, means other innocent angels get a fighting chance.
Cutting-edge DMG research continues to forge ahead at the University of Newcastle, with support from the Little Legs Foundation, together with the Isabella and Marcus Foundation.
Our (LLF) contribution of $26,794 will provide new equipment for Dr Ryan Duchatel and the Dun Lab to investigate the mutations and conditions that converge to trigger the initiation of DMG tumours.
The team will create increasingly sophisticated animal models to allow deeper understanding of how and why DMG tumours specifically form in children and young adults, and work towards developing and evaluating more novel therapies.
So very proud to continue to play a small part in the amazing work of the #dunlab
